Announcement PDF ASX ANNOUNCEMENT Actinogen 2024 AGM – Chair’s address and CEO’s presentation Sydney, 14 November 2024. Actinogen Medical ASX: ACW (“ACW” or “the Company”) is pleased to release the Chair’s address and CEO’s slide presentation to this morning’s Annual General Meeting commencing at 11am (AEDT) in Sydney. The AGM will be held at the offices of K&L Gates, Level 31, 1 O’Connell Street’, Sydney NSW 2000. This AGM is an in-person only meeting. The Chair’s address and CEO’s presentation slides are attached to this announcement. ENDS Dr. Steven Gourlay CEO & Managing Director P: +61 2 8964 7401 E. steven.gourlay@actinogen.com.au Investors Media Michael Roberts Investor Relations M: +61 423 866 231 George Hazim Media & Public Affairs Australia M: +61 417 516 262 E. michael.roberts@actinogen.com.au E: georgehazim@mediaaffairs.com.au Announcement authorised by the Board of Directors of Actinogen Medical About Actinogen Medical Actinogen Medical (ACW) is an ASX-listed, biotechnology company developing a novel therapy for neurological and neuropsychiatric diseases associated with dysregulated brain cortisol. There is a strong association between cortisol and detrimental changes in the brain, affecting cognitive function, harm to brain cells and long-term cognitive health. Cognitive function means how a person understands, remembers and thinks clearly. Cognitive functions include memory, attention, reasoning, awareness and decision-making. Actinogen is currently developing its lead compound, Xanamem, as a promising new therapy for Alzheimer’s Disease and Depression and hopes to study Fragile X Syndrome and other neurological and psychiatric diseases in the future. Reducing cortisol inside brain cells could have a positive impact in these and many other diseases. The cognitive dysfunction, behavioural abnormalities, and neuropsychological burden associated with these conditions is debilitating for patients, and there is a substantial unmet medical need for new and improved treatments. Actinogen Medical Limited ACN 086 778 476 Suite 901, Level 9, 109 Pitt Street, Sydney NSW 2000 +61 2 8964 7401 | actinogen.com.au 1 Current Clinical Trials The XanaCIDD Phase 2a depression trial was a double-blind, six-week proof-of-concept, placebo-controlled, parallel group design trial in 167 patients with moderate, treatment-resistant depression and a degree of baseline cognitive impairment. Participants were evenly randomized to receive Xanamem 10 mg once daily or placebo, in most cases in addition to their existing antidepressant therapy, and effects on cognition and depression were assessed. Trial results were reported in August 2024 and showed clinically and statistically significant benefits on depression symptoms with positive effects on the MADRS scale (a validated scale of depression symptom measurement) and the PGI-S (a valid patient reported assessment of depression severity). The XanaMIA Phase 2b Alzheimer’s disease trial is a double-blind, 36-week treatment, placebo-controlled, parallel group design trial in 220 patients with mild to moderate AD and progressive disease, determined by clinical criteria and confirmed by an elevated level of the pTau181 protein biomarker in blood. Patients receive Xanamem 10 mg or placebo, once daily, and its ability to slow progression of Alzheimer’s disease is assessed with a variety of endpoints. The primary endpoint of the trial is the internationally-recognized CDR-SB (Clinical Dementia Rating scale – Sum of Boxes). The trial is being conducted in Australia and the US. Initial results from an interim analysis of the first 100 participants are anticipated in mid 2025 and final results mid 2026. About Xanamem Xanamem’s novel mechanism of action is to control the level of cortisol in the brain through the inhibition of the cortisol synthesis enzyme, 11β-HSD1, without affecting production of cortisol by the adrenal glands. Xanamem is designed to get into the brain after it is absorbed in the intestines upon swallowing. Chronically elevated cortisol is associated with progression in Alzheimer’s Disease and excess cortisol is known to be toxic to brain cells. Cortisol itself is also associated with depressive symptoms and when targeted via other mechanisms has shown some promise in prior clinical trials. The recent XanaCIDD trial demonstrated clinically and sometimes statistically significant benefits on depressive symptoms. The Company has studied 11β-HSD1 inhibition by Xanamem in more than 380 volunteers and patients in eight clinical trials. Xanamem has a promising safety profile and has demonstrated clinical activity in patients with depression, patients with biomarker-positive Alzheimer’s disease and cognitively normal volunteers. High levels of target engagement in the brain with doses as low as 5 mg daily have been demonstrated in a human PET imaging study. Xanamem is an investigational product and is not approved for use outside of a clinical trial by the FDA or by any global regulatory authority. Xanamem® is a trademark of Actinogen Medical. Disclaimer This announcement and attachments may contain certain "forward-looking statements" that are not historical facts; are based on subjective estimates, assumptions and qualifications; and relate to circumstances and events that have not taken place and may not take place. Such forward looking statements should be considered “at-risk statements” - not to be relied upon as they are subject to known and unknown risks, uncertainties and other factors (such as significant business, economic and competitive uncertainties / contingencies and regulatory and clinical development risks, future outcomes and uncertainties) that may lead to actual results being materially different from any forward looking statement or the performance expressed or implied by such forward looking statements. You are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof. Actinogen Medical does not undertake any obligation to revise such statements to reflect events or any change in circumstances arising after the date hereof, or to reflect the occurrence of or non-occurrence of any future events. Past performance is not a reliable indicator of future performance. Actinogen Medical does not make any guarantee, representation or warranty as to the likelihood of achievement or reasonableness of any forward-looking statements and there can be no assurance or guarantee that any forward-looking statements will be realised. ACTINOGEN MEDICAL ENCOURAGES ALL CURRENT INVESTORS TO GO PAPERLESS BY REGISTERING THEIR DETAILS WITH THE DESIGNATED REGISTRY SERVICE PROVIDER, AUTOMIC GROUP. Actinogen Medical Limited ACN 086 778 476 Suite 901, Level 9, 109 Pitt Street, Sydney NSW 2000 +61 2 8964 7401 | actinogen.com.au 2 14 November 2024 Actinogen 2024 AGM Chair’s Address Good morning, everyone. My name is Geoff Brooke, and I am the Chair of Actinogen Medical Limited. On behalf of the Board of Directors and staff of the Company I welcome shareholders to our 2024 Annual General Meeting. We continue to make compelling progress in the execution of our strategy, focused on “following the science” in the successful development of our novel small molecule drug Xanamem ® for illnesses such as Alzheimer’s disease and depression. We believe that Xanamem’s mechanism of “tissue cortisol control” to reduce excess cortisol inside brain cells has the potential to have a major impact on the lives of the countless patients and their families around the world suffering from many neurological and neuropsychiatric conditions. In addition to our own successes in the last year, it was great to witness gradually improving conditions in the biotech market from the start of 2024, especially as key licensing and M&A activity signalled a change in sentiment from the very challenging market headwinds of 2023, particularly in the small-cap biotech sector. A year of achievement The Company enjoyed a productive financial year with the achievement of several major milestones including the management of two phase 2 trials running concurrently during the second half. It takes significant effort to get a trial to the starting line, let alone manage the complexities of running two sizeable trials across different jurisdictions simultaneously. The XanaCIDD phase 2a depression trial completed its final patient treatment on 1 July 2024, having recruited 167 patients in 16 months – a tremendous effort from our staff, collaborators and the trial participants. An unexpectedly high placebo effect impacted our ability to see a potential Xanamem effect in the cognition primary endpoint. However, in the targeted secondary endpoint, we were very pleased to see positive benefits on depression, providing further evidence to support Xanamem as an effective cortisol control mechanism. Patient recruitment and enrolment activities are ramping up in the XanaMIA phase 2b/3 Alzheimer’s disease trial with four US sites now active in addition to 15 sites in Australia. A further six US sites will be activated before the end of the year, and we expect enrolment to accelerate in the coming months as a result. Another highlight was the approval from the UK Medicines and Healthcare products Regulatory Agency of a UK Innovation Passport, which is the UK version of the FDA’s “breakthrough” designation. This represents a significant independent endorsement by an international regulator of the potential medical importance of the Xanamem program for Alzheimer’s disease. The team has also continued to work diligently to complete two academic manuscripts that were published in the peer-reviewed journal, the Journal of Alzheimer’s Disease in the second half of the financial year, with further academic papers planned. Executive leadership CEO Dr Steven Gourlay has continued to lead the executive team with distinction. He has the relevant experience needed of a biotech CEO for a company in the mid-late stage of clinical development with a view to commercialisation. ® Xanamem is a registered trademark of Actinogen Medical limited Actinogen Medical Limited ACN 086 778 476 Suite 901, Level 9, 109 Pitt Street, Sydney NSW 2000 +61 2 8964 7401 | actinogen.com.au 1 Steve leads a small but innovative, high calibre executive leadership team with complementary skills that produces results. We added to the team’s skillset this year with the appointment in February of the Company’s first full-time Chief Financial Officer, Will Souter, and the recent appointment of Andy Udell as our inaugural Chief Commercial Officer. I also take this opportunity to acknowledge and thank the wider executive leadership team and the Actinogen workforce, as well as key contractors, who all work so diligently to manage a very effective and efficient clinical development program and corporate functions required of a listed biotech. What they are undertaking is no mean feat. They are to be thanked and congratulated. Board, corporate governance and advisory boards I thank my fellow board members for their contributions during a productive year which has necessarily required a significant planning agenda for the next stages in the Company’s development. We maintain a robust corporate governance framework to support the management and execution of our longterm strategy and annual strategic priorities and we will continue to assess our corporate board skillsets and responsibilities including evaluating the Board skills matrix to identify gaps and opportunities for improvement. We also continue to utilise world-leading advisors on our advisory boards to help drive our strategic initiatives and ensure the success of our clinical development program. I thank all our esteemed independent external advisory board and committee members for their important contributions to the success of the Company in FY2024. Capital management The Company successfully completed two capital raisings totalling $18.9 million during the 2024 financial year. In addition, further funding has been received from the conversion of options associated with previous capital raisings. We also recently completed an $11.1 million capital raising comprising an $8.1 million placement and a $3.0 million share purchase plan (SPP) following approval by shareholders at a General Meeting last week. I thank shareholders for your strong support for all our capital raisings during the past 18 months. A further $9.0 million related to the 2024 R&D tax incentive rebate was received earlier this week bringing our cash balance as at 13 November 2024 to $24.5 million. We estimate that the company is funded to at least mid 2026. Notably, Steve Gourlay’s investment of $1 million in the last funding round, which brings his total personal investment in the company to around $2 million, is a clear indication of his belief in the continued success of the Xanamem program. Outlook A key focus in FY2025 will be on progressing our XanaMIA phase 2b/3 Alzheimer’s disease clinical trial as we activate further sites in the USA and ramp up patient screening and enrolments at all locations, ahead of a planned interim analysis in mid 2025. We will also be planning our follow-on activities in our depression trial program by completing the data analysis and exploring the path forward into larger trials in MDD with regulators, global thought leaders and potential strategic partners. The Board looks forward with confidence to a very exciting 2025 financial year. As always, we remain vigilant in our governance and proactive in our management as we deliver on our strategic priorities. On behalf of the Board, I would like to thank you, our shareholders, for your ongoing support, and we look forward to updating you on our progress during the coming year. Actinogen Medical Limited ACN 086 778 476 Suite 901, Level 9, 109 Pitt Street, Sydney NSW 2000 +61 2 8964 7401 | actinogen.com.au 2 Oral Xanamem® Controlling brain cortisol to treat depression and slow progression in Alzheimer’s disease – increasing clinical validation from phase 2 trials AGM CEO Presentation, Steve Gourlay 14 November 2024 ® Xanamem is a registered trademark of Actinogen Medical Limited Disclaimer • This presentation has been prepared by Actinogen Medical Limited. (“Actinogen” or the “Company”) based on information available to it as at the date of this presentation. The information in this presentation is provided in summary form and does not contain all information necessary to make an investment decision. • This presentation does not constitute an offer, invitation, solicitation or recommendation with respect to the purchase or sale of any security in Actinogen, nor does it constitute financial product advice or take into account any individual’s investment objectives, taxation situation, financial situation or needs. An investor must not act on the basis of any matter contained in this presentation but must make its own assessment of Actinogen and conduct its own investigations. Before making an investment decision, investors should consider the appropriateness of the information having regard to their own objectives, financial situation and needs, and seek legal, taxation and financial advice appropriate to their jurisdiction and circumstances. Actinogen is not licensed to provide financial product advice in respect of its securities or any other financial products. Cooling off rights do not apply to the acquisition of Actinogen securities. • Although reasonable care has been taken to ensure that the facts stated in this presentation are accurate and that the opinions expressed are fair and reasonable, no representation or warranty, express or implied, is made as to the fairness, accuracy, completeness or correctness of the information, opinions and conclusions contained in this presentation. To the maximum extent permitted by law, none of Actinogen its officers, directors, employees and agents, nor any other person, accepts any responsibility and liability for the content of this presentation including, without limitation, any liability arising from fault or negligence, for any loss arising from the use of or reliance on any of the information contained in this presentation or otherwise arising in connection with it. • The information presented in this presentation is subject to change without notice and Actinogen does not have any responsibility or obligation to inform you of any matter arising or coming to their notice, after the date of this presentation, which may affect any matter referred to in this presentation. • This presentation is not for general distribution or third party reliance or use. • This presentation contains certain budget information, forecasts and forward looking statements that are based on the Company’s management’s beliefs, assumptions and expectations and on information currently available to management in respect of which there is NO guarantee of future performance. Such budget information, forecasts and forward looking statements involve known and unknown risks, uncertainties, and other factors which may cause the actual results or performance of Actinogen to be materially different from the results or performance expressed or implied by such forward looking statements. These risks and uncertainties include, but are not limited to the performance of Actinogen in its clinical trials including whether it's technology proves to be a safe and effective treatment, market penetration, competition from any other similar products, intellectual property risks (including securing rights in technology and patents) and global economic conditions. Furthermore, Actinogen's research, product development, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. There is no guarantee that Actinogen will obtain the required approvals, licences and registrations from the relevant authorities in jurisdictions in which it operates. Actinogen or others could identify product and efficacy issues relating to the safety of our technology. Accordingly, all forward looking statements are based on numerous assumptions regarding the Company’s present and future business strategies and the political and economic environment in which Actinogen will operate in the future, which are subject to change without notice. Past performance is not necessarily a guide to future performance and no representation or warranty is made as to the likelihood of achievement or reasonableness of any forward looking statements or other forecast. There is no guarantee that Actinogen will achieve its stated objectives/milestones, that any of its forecasts will be met or that forward looking statements will be realised. You are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof, and we do not undertake any obligation to revise and disseminate forward-looking statements to reflect events or circumstances after the date hereof, or to reflect the occurrence of or non-occurrence of any events. • Neither Actinogen nor any other entity or person in or associated with Actinogen guarantee any return (whether capital or income) or generally the performance of Actinogen or the price at which its securities may trade. Any investment in Actinogen is subject to investment risks including the possibility of loss of capital invested and no return of income or payment of any dividends. • To the maximum extent permitted at law, Actinogen and all of its representatives, directors, officers, partners, employees or professional advisers (Parties) exclude all direct and indirect liability arising out of or in connection with any use or reliance of the information contained or described within this presentation. Other than to the extent required by law (and only to that extent), the Parties do not make any representation or give any assurance, guarantee or warranty (express or implied) as to, nor assume any responsibility or liability for, the authenticity, origin, validity, accuracy, suitability or completeness of, or any errors in or omissions from, any information, statement or opinion contained in this presentation or any accompanying, previous or subsequent material or presentation. ACW AGM 14 November 2024 2 Program and 2024’s achievements ACW AGM 14 November 2024 3 Xanamem is now significantly de-risked Novel 11β-HSD1 cortisol control mechanism, oral, attractive safety profile • Brain cortisol has long been proposed as a pathogenic mechanism in Major Depressive Disorder (MDD) and Alzheimer’s (AD) • Unique brain-penetrant tissue cortisol synthesis inhibitor that leaves adrenal cortisol synthesis unaffected • Approximately 400 people treated to date with excellent safety profile and low drug interaction risk Positive phase 2 clinical data de-risk clinical program • Phase 2a MDD1 trial showing clinically & statistically significant activity - benefits across multiple endpoints • Disease-modifying activity on CDR-SB in AD2 phase 2a trial in biomarker-positive AD patients 0.6 points over 12 weeks • Positive data from both trials read through to other indications in psychiatry and the dementias Patent protection and manufacturing • Composition of matter protection to 2031 – to 2036 with extensions in major markets • Additional recent patents protect further against future competition e.g. use patent for MDD • Manufacturing process scaled up and patented, contractors Asymchem (China) & Catalent (US) Large clinical and commercial opportunities • No other brain-penetrant cortisol control molecules are in development • Anti-depressant market is currently ~$20 billion, with major opportunities for novel mechanisms & better-tolerated drugs • Alzheimer’s market likely to be $20 billion by 2030, with major opportunity for a safe & effective oral agent 1. MDD: Major depressive disorde0r 2. Alzheimer’s disease ACW AGM 14 November 2024 4 Accomplishments since June 30 2023 Actinogen is in a strong position Trial & regulatory progress Publications & presentations Commenced enrolment in XanaMIA phase 2b/3 in patients with pTau-positive AD Two peer-reviewed manuscripts in the Journal of Alzheimer’s Disease Opened 15 Australian clinical sites and 4 US sites for XanaMIA with 6 more US in the pipeline 1. Xanamem benefit in pTau-positive patients 2. Human PET study showing full target engagement at low doses Completed XanaCIDD phase 2a with positive benefit on depression symptoms Presented at more than ten scientific and partnering meetings “Innovation passport” status from UK MHRA for AD, FDA protocol approvals Strengthened financial position with ~ $44m1 Key hires Will Souter, CFO Andy Udell, CCO 1. 2. Unless stated otherwise, all financial data is in Australian dollars As at 13 November 2024 Cash on hand $24.5m2 - runway to at least mid 2026 $30m of equity raised across three rounds R&D tax rebate cash received of $13.8m ($4.8m FY23 & $9.0m FY24) ACW AGM 14 November 2024 5 Experienced board and management team Board of Directors Dr. Geoff Brooke Chairman MBBS; MBA Dr. Steven Gourlay CEO & MD MBBS; FRACP; PhD; MBA Mr. Malcolm McComas Non-Executive Director BEc, LLB; FAICD; SF Fin Dr. George Morstyn Non-Executive Director MBBS; PhD; FRACP CD Dr. Nicki Vasquez Non-Executive Director PhD Management Team Dr. Steven Gourlay CEO & MD Dr. Dana Hilt Chief Medical Officer MD Will Souter Chief Financial Officer BComm, LLB Andrew Udell Chief Commercial Officer MBA Cheryl Townsend VP Clinical Operations RN, M Health Law Fujun Li Head of Manufacturing PhD Michael Roberts Head of IR & Comms B.Ec (Hons), CPA, FFIN ACW AGM 14 November 2024 6 Company now in late-stage trials ASX-listed company founded in 2014 • Market Cap $75 million • Cash runway to mid 2026 • Conducted three phase 1 (Australia) and four phase 2 trials (Australia, US and UK) Key shareholders • Biotech Value Fund (BVF) ~8% • CEO Steve Gourlay ~5% (including via ~$2 million invested personally) • Top 20 ex BVF & Gourlay ~23% Phase 2b/3-stage clinical programs are the “sweet spot” for partnering • Alzheimer’s disease (AD) phase 2b/3 on-going – interim ~mid 2025, final results ~mid 2026 • Major depressive disorder (MDD) phase 2a just completed • Type C meeting with FDA to discuss approval requirements early 2025 Fundraising history • Initially Wellcome Trust support for University of Edinburgh • 2014 merger of U Edinburgh spinout Corticrine with Actinogen ASX-listed shell • Equity raises on ASX and Australian R&D tax incentive cash rebates (eg $9 million received this year) ACW AGM 14 November 2024 7 Xanamem - Pipeline Indication Preclinical Phase 1 Phase 2 Phase 3 Next Milestone Results 25-26 Alzheimer’s disease (AD) On-going phase 2b/3 MDD Phase 2a complete, Phase 2b/3 in planning Fragile X syndrome Phase 2a on hold Open INDs FDA Type C in Q1 25 On hold Bipolar disorder PTSD Lewy-body dementia Potential next indications Frontotemporal dementia MDD: Major depressive disorder ACW AGM 14 November 2024 8 Xanamem – AD and MDD Program Timelines* 2024 H1 2025 H2 H1 2026 H2 H1 Final results Interim data Phase 2b/3 Alzheimer’s H2 Phase 3 Alzheimer’s Phase 2a Depression Final results Phase 2b Depression Expert, partner & FDA discussions Phase 3 Depression Ancillary Clinical Pharmacology and Non-clinical Studies PET Trial Publication Phase 2a AD biomarker trial manuscript * Seeking partnership(s) for Phase 2b depression and Phase 3 AD trials which are currently unfunded Other peer-reviewed trial publications ACW AGM 14 November 2024 9 Xanamem is in a class of its own ACW AGM 14 November 2024 10 Xanamem controls cortisol by inhibition of 11β-HSD11 Controlling brain cortisol2 has potential durable benefits “STRESS” in the brain becomes “CHILL” RAPID changes in kinases, cell function, neurotransmitters over hours to days lead to short-term “low stress” settings “Lower stress” shorter term e.g. • Reducing inflammation • Improving neurotransmitter balance • Decreasing cell death SLOW changes in gene expression and protein synthesis over days to weeks lead to durable “low stress” settings “Lower stress” longer term e.g. • Improving neural circuitry • Generating new brain cells • Ideal receptor configurations 1. For a comprehensive review of 11β-HSD1 see Seckl J. 2024 2. Ramamoorthy & Cidlowski 2016 ACW AGM 14 November 2024 11 Human PET study shows full target engagement Other 11β-HSD1 enzyme inhibitors have not achieved adequate brain levels Baseline After 7 days of daily dosing 5 mg Xanamem 10 mg Xanamem 20 mg Xanamem SUVRcarotid Xanamem extensively binds to the 11β-HSD1 enzyme throughout the brain, with high post-treatment effects (absence of colour) after 7 days at all doses, slightly less at a 5 mg dose. This is consistent with full hormonal pharmacodynamic activity seen in clinical trials with doses as low as 5 mg. Journal of Alzheimer’s Disease 97 (2024) 1463–1475 Brain 11-Hydroxysteroid Dehydrogenase Type 1 Occupancy by Xanamem Assessed by PET in Alzheimer’s Disease and Cognitively Normal Individuals Victor L. Villemagne, Vincent Dor, Lee Chong, Michael Kassiou, Rachel Mulligan, Azadeh Feizpour, Jack Taylor, Miriam Roesner, Tamara Miller and Christopher C. Rowe ACW AGM 14 November 2024 12 Conclusions ACW AGM 14 November 2024 13 Positive depression data a boost to both AD and MDD Evidence of durable benefit on depression from control of brain cortisol validates the Xanamem program in terms of:  “Cortisol control” mechanism of action  10 mg daily proof-of-concept dose being used in Alzheimer’s phase 2b/3 trial  10 mg daily dose is also suitable for next depression trial Phase 2a MDD data support further clinical development in MDD Clinical activity on depression supports the likelihood of seeing a disease-modifying effect in Alzheimer’s disease over 36 weeks ACW AGM 14 November 2024 14 What to look forward to in the rest of FY 2025 Xanamem has the potential to be a first & best-in-class treatment for MDD and AD • Regulatory interactions on both MDD and AD with the FDA • Partnering interactions on new MDD data • Accelerating XanaMIA enrolment towards the interim analysis in mid 2025 • Further peer-reviewed publications • Multiple scientific and partnering presentations • Company is now funded to at least mid 2026 ACW AGM 14 November 2024 15 Q&A ACW AGM 14 November 2024 16 Appendix ACW AGM 14 November 2024 17 Key references Other references see also https://actinogen.com.au/xanamem 11β-HSD1 inhibition • Seckl J. 11β-Hydroxysteroid dehydrogenase and the brain: Not (yet) lost in translation. J Intern Med. 2024 Jan;295(1):20-37. doi: 10.1111/joim.13741. Epub 2023 Nov 8. PMID:37941106. https://onlinelibrary.wiley.com/doi/10.1111/joim.13741 • Cognitive and disease-modifying effects of 11β-hydroxysteroid dehydrogenase type 1 inhibition in male Tg2576 mice, a model of Alzheimer’s Disease: Sooy, K., Noble, J., McBride, A., Binnie, M., Yau, J. L. W., Seckl, J. R., Walker, B. R., & Webster, S. P. 2015. Endocrinology, 1-12. • Partial deficiency or short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice Sooy, K., Webster, S. P., Noble, J., Binnie, M., Walker, B. R., Seckl, J. R., & Yau, J. L. W. 2010. Journal of Neuroscience, 30(41), 13867-13872. Xanamem clinical trials • Plasma pTau181 Predicts Clinical Progression in a Phase 2 Randomized Controlled Trial of the 11β-HSD1 Inhibitor Xanamem® for Mild Alzheimer’s Disease Taylor J, Jaros M, Chen C, Harrison J, Hilt D J Alz Dis 2024; 100: 139-150 • Brain 11-Hydroxysteroid Dehydrogenase Type 1 Occupancy by Xanamem Assessed by PET in Alzheimer’s Disease and Cognitively Normal Individuals Villemagne VL, Dore V, Chong L, Kassiouf M, Mulligan, R, Feizpoura A, Taylor J, Roesner M, Miller T, Rowe CC J